Mark Ruffalo’s “I Know This Much Is True” Adds to Cast

The limited series has banked some major talent. 

Variety confirms that Melissa Leo, Rosie O’Donnell, Archie Panjabi, Imogen Poots, Juliette Lewis and Kathryn Hahn will star opposite Mark Ruffalo in I Know This Much Is True.

The six-episode limited drama series was given a production commitment from HBO. It is based on Wally Lamb’s bestselling book of the same name. The family drama follows the parallel lives of identical twin brothers in a story of betrayal, sacrifice, and forgiveness, taking place against the backdrop of 20th century America.

Ruffalo stars as twin brothers Dominick and Thomas Birdsey; Leo will play Ma, mother of Dominick and Thomas; O’Donnell portrays Lisa Sheffer, a social worker for unit two at the Hatch Forensic Institute where Thomas is staying; Panjabi is Dr. Patel, Thomas’ newly appointed psychologist; Poots will play Joy Hanks, Dominick’s live-in girlfriend; Lewis is Nedra Frank, a self-absorbed grad student hired by Dominick; and Hahn portrays Dessa Constantine, Dominick’s ex-wife.

The limited series is directed, written and executive produced by Derek Cianfrance. Ruffalo and Wally are also exec producing.